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pentobarbital will decrease the level or effect of brexpiprazole by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Intently. Double brexpiprazole dose over 1-2 months if administered with a powerful CYP3A4 inducer.pentobarbital will lower the extent or effect of alosetron by influencing hepatic enzyme CYP2C9/10 metabo